BiochemistryACS Chemical BiologyPeer-reviewed
Selectivity of the time-dependent M. tuberculosis LeuRS inhibitor ganfeborole is driven by target vulnerability
Mingqian Wang, YongLe He, Siobhan A. Cohen…·Peter J. Tonge
This paper shows ganfeborole is a potent time-dependent inhibitor of M. tuberculosis LeuRS with a long post-antibiotic effect, but not effective against E. coli despite inhibiting its LeuRS.