Jin Won Kim

Loss of p21-activated kinase 4 (PAK4) suppresses pancreatic tumor progression and metastasis through regulating E-cadherin

This study shows that PAK4 promotes pancreatic cancer metastasis by reducing E-cadherin, and its loss inhibits tumor progression and metastasis.

VEGFR2 blockade overcomes acquired KRAS G12D inhibitor resistance driven by PI3Kγ activation

This paper identifies VEGFA-VEGFR2 signaling driven by PI3Kγ activation as a mechanism of acquired resistance to KRAS G12D inhibitors and shows that blocking this pathway restores drug sensitivity in resistant cancer models.

Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

This study traces the evolutionary paths of gallbladder adenocarcinomas, showing subclonal diversification and selection from precancerous lesions to metastatic tumors.