Author

Se Hyun Kim

Seoul National UniversityORCID 0000-0002-2292-906XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Jee Hyun KimiD· 3 shared Jin Won KimiD· 3 shared Koung Jin SuhiD· 3 shared Yu Jung KimiD· 3 shared Eun Hee JungiD· 2 shared Hee Young NaiD· 2 shared Keun‐Wook LeeiD· 2 shared Kui‐Jin KimiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Jee Hyun KimORCID

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4 papers

Recent·Most cited

Loss of p21-activated kinase 4 (PAK4) suppresses pancreatic tumor progression and metastasis through regulating E-cadherin

Kui‐Jin Kim, Cheng Hyun Lee, Hee Young Na, Ji Hea Sung, Bo‐Ram Park, Sung-Hyun Hwang, Woochan Park, 서정민, Minsu Kang, Eun Hee Jung, Sang‐A Kim, Koung Jin Suh, Ji Yun Lee, Se Hyun Kim, Jeong-Ok Lee, , Jin Won Kim

This study shows that PAK4 promotes pancreatic cancer metastasis by reducing E-cadherin, and its loss inhibits tumor progression and metastasis.

Cancer Gene Therapy · Oct 31, 2026Peer-reviewedCancer Biology

VEGFR2 blockade overcomes acquired KRAS G12D inhibitor resistance driven by PI3Kγ activation

Sung‐Hyun Hwang, Mingyun Bae, Ji‐Won Kim, Seung Yoon Hyun, Kui‐Jin Kim, Joshua H. Choe, Min Jung Kim, Ji Won Park, Seung‐Yong Jeong, Songji Choi, Woochan Park, Jeongmin Seo, Heejung Chae, Min-Su Kang, Eun Hee Jung, , Keun‐Wook Lee

This paper identifies VEGFA-VEGFR2 signaling driven by PI3Kγ activation as a mechanism of acquired resistance to KRAS G12D inhibitors and shows that blocking this pathway restores drug sensitivity in resistant cancer models.

bioRxiv · Sep 16, 2025 · PreprintCancer Biology

Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

Min-Su Kang, Hee Young Na, Soomin Ahn, Ji-Won Kim, Ju Hyun Lee, 안소연, Jeonghwan Youk, Haesook T. Kim, Se Hyun Kim, Koung Jin Suh, J Y Lee, Jin Won Kim, Yu Jung Kim, Keun‐Wook Lee, Jong Seok Lee, , Ho‐Seong Han

This study traces the evolutionary paths of gallbladder adenocarcinomas, showing subclonal diversification and selection from precancerous lesions to metastatic tumors.

eLife · Dec 8, 2022Peer-reviewedGenetics

Improving Polygenic Prediction in Ancestrally Diverse Populations

Yunfeng Ruan, Kuang Lin, Yen‐Chen Anne Feng, Chia‐Yen Chen, Max Lam, Zhenglin Guo, Stanley Global Asia Initiatives, Yong Min Ahn, Kazufumi Akiyama, Makoto Arai, Ji Hyun Baek, Wei J. Chen, Young‐Chul Chung, Gang Feng, Kumiko Fujii, , Tian Ge

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Nature Genetics · May 1, 2022Peer-reviewedGenetic & Genomic Medicine