Author

Ailin Lepletier

Griffith UniversityORCID 0000-0002-1371-7313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

Manisha PandeyiD· 2 shared Michael F. GoodiD· 2 shared Ahmed MohamediD· 1 shared Ainslie Callcutt· 1 shared Andrew C. SteeriD· 1 shared Bhagya Senadheera· 1 shared Daniel KolarichiD· 1 shared Darrell Bassette· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Manisha PandeyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Sub-clinical exposure to Streptococcus pyogenes drives the development of immunity

Ailin Lepletier, Despena Vedis, Victoria Ozberk, Merrina Anugraham, Darrell Bassette, Ainslie Callcutt, Hannah R. C. Frost, Kristy I. Azzopardi, Andrew C. Steer, Daniel Kolarich, Joshua Osowicki, Michael F. Good, Manisha Pandey

The paper shows that sub-clinical exposure to Streptococcus pyogenes generates functional immune responses and contributes to immunity by adulthood.

bioRxiv · Jul 2, 2025 · PreprintMicrobiology

Immunotherapeutic strategy to prevent progression and complications of acute rheumatic fever

Rukshan Ahamed Mohamed Rafeek, Natkunam Ketheesan, Michael F. Good, Manisha Pandey, Ailin Lepletier

This study investigates low-dose interleukin 2 (LD-IL-2) as an immunotherapeutic intervention in a rat model of acute rheumatic fever, showing reduced cardiac inflammation and increased regulatory T-cells.

mBio · Feb 25, 2025Peer-reviewedImmunology

Integrative proteomics and transcriptomics of human T-cells reveals temporal metabolic reprogramming following TCR-induced activation

Harshi Thilanka Welegedara Weerakoon, Ahmed Mohamed, Yide Wong, Bhagya Senadheera, Oscar L. Haigh, Thomas S. Watkins, Stephen H. Kazakoff, Pamela Mukhopadhyay, Jason P. Mulvenna, John J. Miles, Michelle Mei Chih Hill, Ailin Lepletier

This study integrates proteomic and transcriptomic data from human T-cells to show time-dependent metabolic reprogramming and divergence in gene expression during activation.

bioRxiv · Mar 17, 2023 · PreprintSystems Biology