Joshua Osowicki

This study identifies changes in the salivary proteome during Streptococcus pyogenes infection, revealing inflammatory responses and virulence factor interactions.

The paper characterizes and manufactures a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model, selecting a suitable isolate and validating a manufacturing workflow.

This study compares S. pyogenes infection responses in airway and alveolar epithelial cells, finding that alveolar cells show higher cell death and a pro-inflammatory response without cytokine secretion, and that IFN-β treatment reduces infection.

The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.

The paper shows that sub-clinical exposure to Streptococcus pyogenes generates functional immune responses and contributes to immunity by adulthood.

The paper examines antibody responses to S. pyogenes antigens in individuals with and without pharyngitis, finding differences in IgG and IgA levels and correlations with prior immunity.

This paper identifies M. ulcerans JKD8049 as a suitable human challenge strain for Buruli ulcer research due to its stability, antibiotic susceptibility, and ability to produce mycolactone.