Kristy I. Azzopardi

Streptococcus pyogenes transforms the salivary proteome during controlled human infection

This study identifies changes in the salivary proteome during Streptococcus pyogenes infection, revealing inflammatory responses and virulence factor interactions.

Characterisation and manufacture of a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model

The paper characterizes and manufactures a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model, selecting a suitable isolate and validating a manufacturing workflow.

Attenuated interferon signalling in alveolar epithelium limits resistance to Streptococcus pyogenes

This study compares S. pyogenes infection responses in airway and alveolar epithelial cells, finding that alveolar cells show higher cell death and a pro-inflammatory response without cytokine secretion, and that IFN-β treatment reduces infection.

Sub-clinical exposure to Streptococcus pyogenes drives the development of immunity

The paper shows that sub-clinical exposure to Streptococcus pyogenes generates functional immune responses and contributes to immunity by adulthood.

Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.

The paper examines antibody responses to S. pyogenes antigens in individuals with and without pharyngitis, finding differences in IgG and IgA levels and correlations with prior immunity.