Author

Daniel H. Lin

Howard Hughes Medical InstituteORCID 0000-0002-1393-3374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

David P. BarteliD· 3 shared Brenda Arlene SchulmaniD· 1 shared David M. SabatiniiD· 1 shared Ekaterina KhalizevaiD· 1 shared Elena SlobodyanyukiD· 1 shared Eleonora NardiniiD· 1 shared G. Jordan RayiD· 1 shared Heather R. KeysiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

David P. BartelORCID

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3 papers

Recent·Most cited

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation

Jakob Farnung, Elena Slobodyanyuk, Peter Y. Wang, Lianne W. Blodgett, Daniel H. Lin, Susanne von Gronau, Brenda Arlene Schulman, David P. Bartel

This paper identifies how a human AGO-miRNA-trigger complex binds ZSWIM8 for CUL3-mediated polyubiquitylation, leading to target-directed miRNA degradation.

bioRxiv · Jan 5, 2026 · PreprintBiochemistry

mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth

Daniel H. Lin, Lara E. Elcavage, Ekaterina Khalizeva, David P. Bartel

The paper identifies and validates new TDMD-triggering sites in mouse models, showing their role in microRNA degradation and growth regulation through imprinted gene networks.

bioRxiv · Nov 6, 2025 · PreprintMolecular Biology

Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation

G. Jordan Ray, Eleonora Nardini, Heather R. Keys, Daniel H. Lin, David M. Sabatini, David P. Bartel

This study identifies lysosomal RNases and shows specific RNA types are targeted for degradation via autophagy-dependent mechanisms.

bioRxiv · Sep 9, 2025 · PreprintMolecular Biology