Jorge Bernardino de la Serna

This study shows that protein crowding reduces lipid order in membranes, eliminating the liquid-gel phase transition similar to cholesterol's effect.

This study shows that BPGA, a cherry-flavoured e-cigarette adduct, induces oxidative stress, inflammation, and EMT-like changes in alveolar epithelial cells, potentially contributing to lung injury and fibrosis.

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

This study uses molecular dynamics simulations to reveal how misfolded α1-antitrypsin forms liquid-like droplets that harden into solid clusters, explaining the pathogenesis of α1-antitrypsin deficiency.

This study identifies and validates cholesterol binding sites on GLP-1R in pancreatic beta cells, showing their role in receptor function and potential for drug design.

This paper introduces a microfluidic airway smooth muscle-on-a-chip model to study ASM remodelling and dysfunction in respiratory diseases.

The paper develops a dynamic breathing Exposure-on-a-Chip to study nanoparticle deposition in alveoli, finding that mechanical stretching reduces nanoparticle accumulation in cells.

This study uses molecular dynamics simulations, Langmuir trough measurements, and AFM imaging to analyze lateral heterogeneity in synthetic pulmonary surfactant monolayers, revealing structural and dynamic differences between liquid-condensed and liquid-expanded regions.

This study develops a live-cell method to assess keratinocyte differentiation using membrane packing order as a marker, applicable at single-cell and high-throughput levels.

This paper optimizes processing and analysis of scanning FCS data, introducing FoCuS-scan software and addressing bias and variance in diffusion measurements.