Haley Appel

This study shows Ptbp1 is not required for retinal neurogenesis or cell fate specification, contradicting prior claims of its role as a master regulator.

This study shows that GFAP promoter-driven AAV constructs in adult mouse retina show insert-dependent expression in non-glial cells without evidence of glia-to-neuron conversion.

This study identifies gene regulatory networks controlling retinal development by integrating single-cell RNA and ATAC-seq data from mouse and human retinas, revealing transcription factors that regulate temporal patterning and cell fate.

This study shows that deleting Ptbp1 in adult retinal Muller glia and brain astrocytes does not convert glia into neurons, using genetic lineage tracing, scRNA-Seq, and electrophysiology.