Jean‐Philippe Hugnot

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

This study identifies a non-catalytic role for Rad18 in sustaining glioblastoma proliferation and proposes it as a therapeutic target.

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

The paper introduces ccAFv2, a high-resolution cell cycle classifier for scRNA-seq data, which outperforms existing methods and classifies six cell cycle states and a quiescent-like G0 state.

The paper shows that FoxJ1+ Pax6+ Sox2+ ependymal cells persist in the human spinal cord throughout life, maintaining neurodevelopmental gene expression and structural features similar to those in mice and young humans.