Leonor Garcia

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

The paper introduces ccAFv2, a high-resolution cell cycle classifier for scRNA-seq data, which outperforms existing methods and classifies six cell cycle states and a quiescent-like G0 state.