Oren S. Rosenberg

This study investigates how SegA and SegB proteins in Sulfolobus acidocaldarius work together to segregate chromosomes, revealing a bipolar structure distinct from bacterial systems.

This study uses single-cell RNA sequencing to show that M. tuberculosis ESX-1 promotes the recruitment and differentiation of anti-inflammatory macrophages in infected mouse lungs.

This study identifies Pseudomonas aeruginosa genes whose partial knockdown increases vulnerability in a murine pneumonia model, highlighting potential targets for antibacterial strategies.

This study performs a deep mutational scan on EccD3 in M. smegmatis to understand its role in the ESX-3 secretion system and its importance for mycobacterial survival.

This study uses Perturb-seq to functionally interrogate SARS-CoV-2 host factors in human lung epithelial cells, identifying key factors that influence infection and host response.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

Inserting theophylline aptamers into the sgRNA yields ligand-activated and ligand-deactivated guides that tune CRISPRi in E. coli over 11x to 13x dynamic ranges, enabling two-ligand multiplexing.