Author

Caitlin M. O’Shea

University of EssexORCID 0000-0002-1447-6814Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Gareth S. A. WrightiD· 2 shared Daryl A. BoscoiD· 1 shared Fiona E. BensoniD· 1 shared Greg Nicholas BrookeiD· 1 shared Hidenori IchijoiD· 1 shared James S. TrimmeriD· 1 shared Jiraporn PanmaneeiD· 1 shared Kimia Aghasoleimani· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Gareth S. A. WrightORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedJan 31, 2026

Reliable repurposing of the antibody interactome inside the cell

Caitlin M. O’Shea, Rushba Shahzad, Kimia Aghasoleimani…·Gareth S. A. Wright

The paper develops methods to improve the solubility and stability of intrabodies by optimizing linker design, domain orientation, and charge properties, enabling effective intracellular targeting of cytoplasmic proteins.

1 citation

humanproteomics

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Molecular BiologybioRxivPreprintNov 13, 2025

A biological PROTAC for α-synuclein.

Caitlin M. O’Shea, Gareth S. A. Wright

This paper describes a bioPROTAC targeting α-synuclein that reduces its abundance and aggregates in cell-type dependent manner, but fails for other targets like SOD1 and LMO2.

2 citations

protein structureexperimental assay

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