Author

Gareth S. A. Wright

University of EssexORCID 0000-0002-3756-9634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Caitlin M. O’SheaiD· 2 shared Adam J. SimpkiniD· 1 shared Alan CartmelliD· 1 shared Alexander CaseiD· 1 shared Ana Sofia LuisiD· 1 shared Charles W.E. TomlinsoniD· 1 shared Christoph G. BaumanniD· 1 shared Chunsheng JiniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Caitlin M. O’SheaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Reliable repurposing of the antibody interactome inside the cell

Caitlin M. O’Shea, Rushba Shahzad, Kimia Aghasoleimani, Stuart Newman, Jiraporn Panmanee, Leonard C. Schalkwyk, Greg Nicholas Brooke, Fiona E. Benson, James S. Trimmer, Daryl A. Bosco, Takao Fujisawa, Hidenori Ichijo, Neil R. Cashman, Stanislav Engel, Gareth S. A. Wright

The paper develops methods to improve the solubility and stability of intrabodies by optimizing linker design, domain orientation, and charge properties, enabling effective intracellular targeting of cytoplasmic proteins.

Nature Communications · Jan 31, 2026Peer-reviewedMolecular Biology

A biological PROTAC for α-synuclein.

Caitlin M. O’Shea, Gareth S. A. Wright

This paper describes a bioPROTAC targeting α-synuclein that reduces its abundance and aggregates in cell-type dependent manner, but fails for other targets like SOD1 and LMO2.

bioRxiv · Nov 13, 2025 · PreprintMolecular Biology

The role of Akkermansia muciniphila sulfatases in colonic mucinutilisation

Debajit Dey, Naba D. Salman, Charles W.E. Tomlinson, Chunsheng Jin, Grete Raba, Sadie R. Schaus, Marcus Nilsson, Zak McIver, Adam J. Simpkin, Matthew Davy, Daniel John Rigden, Mirjam Czjzek, Dominic P. Byrne, Mihai Oltean, Alexander Case, , Alan Cartmell

This study investigates the role of Akkermansia muciniphila sulfatases in colonic mucin utilization, revealing unique adaptations compared to Bacteroides species.

bioRxiv · Sep 11, 2025 · PreprintBiochemistry