Author

Jana Ziegelmüller

University of BernORCID 0000-0002-2875-7545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein design· 2 Assay:protein sequence· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Oliver MühlemanniD· 3 shared Evangelos D. KarousisiD· 2 shared Lukas‐Adrian GurzeleriD· 2 shared Alexander M. HoferiD· 1 shared Anne‐Christine UldryiD· 1 shared Christelle Gasser-Didierlaurant· 1 shared Christian N. ParkeriD· 1 shared Francis BitschiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMolecular Biology

Oliver MühlemannORCID

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3 papers

Recent·Most cited

Efficient cell-free translation from diverse human cell types

Jana Ziegelmüller, Nikolaos Kouvelas, Nino Schwaller, Priyanka Thambythurai, Alexander M. Hofer, Oliver Mühlemann, Evangelos D. Karousis

The paper presents a scalable method for preparing cell-type-specific lysates from human cell lines to improve cell-free translation systems.

Journal of Biological Chemistry · May 28, 2025Peer-reviewedBiochemistry

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

Lukas‐Adrian Gurzeler, Marion Link, Yvonne Ibig, Isabel Schmidt, Olaf Galuba, Julian Schoenbett, Christelle Gasser-Didierlaurant, Christian N. Parker, Xiaohong Mao, Francis Bitsch, Markus Schirle, Philippe Couttet, Frederic D. Sigoillot, Jana Ziegelmüller, Anne‐Christine Uldry, , Jürgen Reinhardt

The paper introduces two novel readthrough promoters that induce eRF1 degradation, leading to PTC suppression and revealing a new ribosome quality control mechanism.

Cell Reports · Aug 30, 2023Peer-reviewedMolecular Biology

Production of human translation-competent lysates using dual centrifugation

Lukas‐Adrian Gurzeler, Jana Ziegelmüller, Oliver Mühlemann, Evangelos D. Karousis

This paper introduces a dual centrifugation method to produce human translation-competent lysates, enabling efficient mRNA translation in both cap-dependent and IRES-mediated ways.

RNA Biology · Dec 29, 2021Peer-reviewedMolecular Biology