Excitatory GABAergic signalling is associated with acquired benzodiazepine resistance in status epilepticus
Richard Joseph Burman, Joshua S Selfe, John Hamin Lee, Maurits M. van den Berg, Alexandru Calin, Neela Krushna Codadu, Rebecca Wright, Sarah E. Newey, R. Ryley Parrish, Arieh Anthony Katz, Jo M. Wilmshurst, Colin J. Akerman, Andrew J. Trevelyan, Joseph V. Raimondo
The paper investigates the cellular mechanisms of benzodiazepine resistance in status epilepticus, finding that persistent high intraneuronal chloride levels contribute to reduced GABAA receptor function and enhanced epileptiform activity.
Brain · Sep 5, 2019Peer-reviewedNeuroscience