Author

Miguel Pachon‐Penalba

Wellcome Centre for Cell BiologyORCID 0000-0002-1499-0880Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:Arabidopsis· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Owen Richard DaviesiD· 2 shared Urszula Lucja McClurgiD· 2 shared Amanda Thomaz· 1 shared Amy E. MilburniD· 1 shared Andrew B. FieldingiD· 1 shared Andrew D. Bates· 1 shared Carmen Espejo-SerranoiD· 1 shared Claudia Guterres Nogueira· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Owen Richard DaviesORCID

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Author profile →

2 papers

Recent·Most cited

Molecular architecture of meiotic pro-crossover factor HEI10 reveals coupling of higher-order assembly and ubiquitin chain formation

Amy E. Milburn, Dhananjaya S. Kulkarni, Carmen Espejo-Serrano, Miguel Pachon‐Penalba, Moli Williams, Jonatha P O Nicol, Simona Debilio, Manickam Gurusaran, James M. Dunce, Ian R. Adams, Urszula Lucja McClurg, Neil Hunter, Owen Richard Davies

This study determines the molecular structure and function of HEI10, revealing its role in ubiquitin chain formation during meiosis.

bioRxiv · May 10, 2026 · PreprintBiochemistry

Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug Resistance

Urszula Lucja McClurg, Wee-Wei Tee, Owen Richard Davies, Louise Brennan, OV Grinchuk, Miguel Pachon‐Penalba, Ieng Fong Sou, Conor J. Fawcett, Claudia Guterres Nogueira, Megan Guthrie, Andrew D. Bates, Megan Hine, Amanda Thomaz, Andrew B. Fielding

This study identifies SYCP1 as a chromatin-bound regulator in breast cancer that promotes DNA repair, transcription, and drug resistance, with clinical implications for prognosis and therapy.

bioRxiv · Sep 18, 2025Cancer Biology