Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug Resistance
Urszula Lucja McClurg, Wee-Wei Tee, Owen Richard Davies, Louise Brennan, OV Grinchuk, Miguel Pachon‐Penalba, Ieng Fong Sou, Conor J. Fawcett, Claudia Guterres Nogueira, Megan Guthrie, Andrew D. Bates, Megan Hine, Amanda Thomaz, Andrew B. Fielding
This study identifies SYCP1 as a chromatin-bound regulator in breast cancer that promotes DNA repair, transcription, and drug resistance, with clinical implications for prognosis and therapy.
bioRxiv · Sep 18, 2025Cancer Biology