Natalia A. Szulc

A dosage-sensitive ALLO-1 network coordinates mitochondrial quality control to enable functional recovery of structurally compromised muscle

The paper identifies an ALLO-1 network that coordinates mitochondrial quality control in C. elegans muscle, enabling functional recovery despite structural damage.

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub

This paper shows that the nucleolus becomes a stress-responsive proteostasis hub during heat shock, regulated by CHIP, VCP, and gatekeepers like NOL6 and WDR55.

Tissue-specific consequences of tag fusions on protein expression in transgenic mice

The paper shows that tag fusions can have tissue-specific effects on protein stability in transgenic mice, depending on the cell and tissue environment.

DEGRONOPEDIA - a web server for proteome-wide inspection of degrons

DEGRONOPEDIA provides a web server for analyzing degron motifs across seven model organisms, integrating sequence, structure, and modification data to support degron research.

Sterility-Independent Enhancement of Proteasome Function via Floxuridine-Triggered Detoxification in C. elegans

This study shows that floxuridine enhances proteasome function in C. elegans, improves cold survival, and activates a detoxification pathway independent of SKN-1 and the germline.

Structural Interaction Fingerprints and Machine Learning for predicting and explaining binding of small molecule ligands to RNA

The paper develops SIFt-based machine learning models to predict RNA-ligand binding and provides a benchmark dataset for virtual screening.

Lysine-deficient proteome can be regulated through non-canonical ubiquitination and ubiquitin-independent proteasomal degradation

The paper identifies lysine deserts in UPS components across species and shows they can be regulated by non-lysine ubiquitination and ubiquitin-independent proteasomal degradation.

Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity

The paper investigates how the CHN-1/UFD-2 complex enhances ubiquitin chain formation through dimerization and chaperone-mediated regulation of substrate ubiquitylation.

fingeRNAt - a novel tool for high-throughput analysis of nucleic acid-ligand interactions

The paper introduces fingeRNAt, a tool for detecting non-covalent interactions in nucleic acid-ligand complexes and presents its applications for high-throughput analysis and similarity measurement.

A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia

The paper identifies a de novo FEM1C variant linked to neurodevelopmental disorder and shows its pathogenicity using in vitro and in vivo models.