Author

Merina Varghese

Icahn School of Medicine at Mount SinaiORCID 0000-0002-1517-3903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Patrick R. HofiD· 3 shared Adrian Vasile DalcaiD· 1 shared Akiko AsadaiD· 1 shared Alejandro Borja Grau-PeralesiD· 1 shared Alexander J. RopelewskiiD· 1 shared Ambrose CarriD· 1 shared Ana Catarina FerreiraiD· 1 shared Anderson CheniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersNeuroscience

Patrick R. HofORCID

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4 papers

Recent·Most cited

NeuroscienceAlzheimer s & DementiaPeer-reviewedJun 1, 2026

Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Emilie L. Castranio, Merina Varghese, Elentina K. Argyrousi…·Michelle E. Ehrlich

This study shows that nonfibrillar Aβ aggregates in APPE693Q mice disrupt presynaptic function without causing inflammation.

2 citationstop 4%

mousebulk RNA-seq

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NeuroscienceMolecular PsychiatryPeer-reviewedSep 1, 2023

Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

Ana Catarina Ferreira, Brittany M. Hemmer, Sarah M. Philippi…·Joseph M. Castellano

This study shows that neuronal TIMP2 regulates hippocampus-dependent memory by controlling extracellular matrix accumulation and adult neurogenesis.

31 citationstop 5%

mouseexperimental assay

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BioinformaticsbioRxivPreprintOct 26, 2022

The BRAIN Initiative Cell Census Data Ecosystem: A User's Guide

Michael Hawrylycz, Maryann Elizabeth Martone, Patrick R. Hof…·Brian Zingg

The paper provides a guide to the BRAIN Initiative Cell Census Network (BICCN) data ecosystem, its tools, and resources for analyzing brain cell types across species.

7 citations

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NeurosciencebioRxivPreprintOct 20, 2021

A multimodal imaging and analysis pipeline for creating a cellular census of the human cerebral cortex

Irene Costantini, Leah Morgan, Jiarui Yang…·Patrick R. Hof

The paper develops an imaging pipeline to create a cell census of the human cerebral cortex using MRI, immunohistochemistry, and light-sheet fluorescence microscopy.

6 citations

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