Jian Zhou

Sialin2 Functions as a Mammalian Nitrate Sensor to Sustain Mitochondrial Homeostasis

The paper identifies Sialin2 as a mammalian nitrate sensor that sustains mitochondrial homeostasis by activating AMPK and enhancing mitochondrial function.

Sialin2 Senses Nitrate to Activate Endosomal PI3K-AKT-NOS Signaling

This study identifies Sialin2 as a mammalian nitrate sensor that activates endosomal PI3K-AKT-NOS signaling to enhance angiogenesis and cell survival, offering new therapeutic strategies for vascular disorders.

ISCO: Intelligent Framework for Accurate Segmentation and Comparative Analysis of Organoids

ISCO provides an AI-driven tool for automated organoid segmentation and morphological analysis to improve efficiency and standardization in organoid research.

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

This study identifies Gdf11 as a MeCP2-regulated gene critical for neurological function, showing that altering its dosage affects behavior and longevity in mouse models.