Rodrigo Senovilla-Ganzo

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

This study identifies a proliferative-to-quiescent switch in microglial development and links it to epigenetic regulation and phagocytic function.

This paper integrates five vertebrate single-cell multi-omic atlases to reveal a conserved cellular blueprint and dual evolutionary constraints underlying early brain conservation across vertebrates.

This study shows GABAB receptors have dual roles in oligodendrocyte function and immune modulation in experimental MS, with baclofen showing therapeutic potential in reducing disease severity and promoting remyelination.

This study compares the development and evolution of sensory circuits in the pallium of birds, lizards, and mammals, revealing divergent developmental trajectories but functional similarity in sensory processing.

The paper characterizes the avian pallium's cell types and evolution using single-cell and spatial transcriptomics, revealing conserved and divergent features across amniotes.

This study shows that amyloid-beta oligomers disrupt RNA dynamics in oligodendrocytes by altering hnRNP A2 interactions, leading to increased translation of myelin proteins MBP and MOBP.

The paper identifies hippocampal reactive neural stem cells (react-NSCs) as phagocytic and immunologically active cells in two pathological models, MTLE and TBI.

BirthSeq isolates and analyzes cells based on their birth date across vertebrate tissues, enabling temporal studies of cell fate in development.

The paper identifies functionally conserved non-homologous lncRNAs across species using k-mer content and structural analysis, validated through CRISPR Display in human and chicken cells.