This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

medRxiv · Jul 9, 2026 · PreprintGenetic & Genomic Medicine

Collablots: Quantification of collagen VI levels and its structural disorganisation in cell cultures from patients with collagen VI-related dystrophies

Nadia Osegui‐Barcenilla, Maria Sendino, Sergio Martín‐González, Itziar González‐Moro, Ainhoa Benito‐Agustino, Noemi Torres‐Conde, Andrea López‐Martínez, Cecilia Jimenez-Mallebrera, Arístides López‐Márquez, Virginia Arechavala‐Gomeza

This paper introduces a method called collablot to quantify collagen VI levels and structural disorganisation in cell cultures from patients with collagen VI-related dystrophies, showing its effectiveness in detecting treatment effects and structural changes.

Neuropathology and Applied Neurobiology · May 22, 2025Peer-reviewedNeuroscience

The type 1 diabetes-associated lncRNA ARGI participates in virus-induced pancreatic beta cell inflammation.

Itziar González‐Moro, Koldo García‐Etxebarria, Luis Manuel Mendoza, Nora Fernández‐Jiménez, Jon Mentxaka, Ane Olazagoitia‐Garmendia, María Nicol Arroyo, Toshiaki Sawatani, Cristina Moreno‐Castro, Chiara Vinci, Anne Op De Beeck, Miriam Cnop, Mariana Igoillo‐Esteve, Izortze Santín

This study identifies the lncRNA ARGI as a mediator of virus-induced inflammation in pancreatic beta cells linked to type 1 diabetes through allele-specific transcriptional activation.

Advanced Science · Jun 29, 2023Peer-reviewedGenetics