NOTCH1-specific phosphorylation of S1970 by Casein Kinase 1 is required for NOTCH1 transcriptional competence and signaling activity in vivo
Fabio Turetti, Lorena Agostini Maia, Hana Hajsmanova, Jakub Sławski, Wim Dehaen, Marek Dokoupil, Giovanna M. Collu, Tomáš Gybeľ, Kamil Paruch, Emma Rachel Andersson, Vı́tězslav Bryja, Pavla Perlíková, Konstantinos Tripsianes, Jakub Harnoš, Jan Mašek
This study identifies CK1-mediated phosphorylation of NOTCH1 at S1970 as essential for its transcriptional activity and signaling in vivo.
bioRxiv · May 7, 2026 · PreprintCell Biology