Author

Kamil Paruch

Masaryk UniversityORCID 0000-0001-9502-3173Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Organism:Xenopus· 1

Frequent Co-Authors

Alexandra Sisáková· 1 shared Benoît CarbainiD· 1 shared Claus M. AzzaliniD· 1 shared Emma Rachel AnderssoniD· 1 shared Fabio TurettiiD· 1 shared Fedor Nikulenkov· 1 shared Giovanna M. ColluiD· 1 shared Hana HajsmanovaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alexandra Sisáková

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2 papers

Recent·Most cited

NOTCH1-specific phosphorylation of S1970 by Casein Kinase 1 is required for NOTCH1 transcriptional competence and signaling activity in vivo

Fabio Turetti, Lorena Agostini Maia, Hana Hajsmanova, Jakub Sławski, Wim Dehaen, Marek Dokoupil, Giovanna M. Collu, Tomáš Gybeľ, Kamil Paruch, Emma Rachel Andersson, Vı́tězslav Bryja, Pavla Perlíková, Konstantinos Tripsianes, Jakub Harnoš, Jan Mašek

This study identifies CK1-mediated phosphorylation of NOTCH1 at S1970 as essential for its transcriptional activity and signaling in vivo.

bioRxiv · May 7, 2026 · PreprintCell Biology

Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells

Jana Prochazkova, Benoît Carbain, Victoria Marini, Fedor Nikulenkov, Štěpán Havel, Naresh Akavaram, Prashant Khirsariya, Alexandra Sisáková, Jakub Cibulka, Michala Boudova, Magdalena Zacpalova, Magdalena Kalovska, Joana Rodrigues, Lukáš Daniel, Jan Brezovský, , Lumír Krejčí

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

Journal of Medicinal Chemistry · Feb 25, 2026Peer-reviewedMolecular Biology