This study conducts a GWAS meta-analysis of stuttering, identifying genetic links with speech disorders and highlighting shared genetic architecture across different ascertainment methods.

medRxiv · Sep 16, 2026 · PreprintGenetic & Genomic Medicine

Common Variant Contributions to Neurodevelopmental Risk in Orofacial Clefts

Alexandros Rammos, Sarah Jane Lewis, Amy Davies, Yvonne E. Wren, Kerry Humphries, Jonathan R. Sandy, Gemma C. Sharp, Michael John Owen, Marianne B. M. van den Bree, Evie Stergiakouli

The paper investigates whether common genetic variants contribute to neurodevelopmental risks in children with cleft lip/palate, finding no strong genetic correlation with psychiatric traits but noting independent clinical relevance of polygenic risk scores.

BMC Medicine · Sep 9, 2026Peer-reviewedGenetic & Genomic Medicine

Genetic Heterogeneity and Homogeneity Among Orofacial Cleft Subtypes: Genome-Wide Association Studies in the Cleft Collective

Kyle Dack, Kerstin U. Ludwig, Evie Stergiakouli, Jonathan R. Sandy, Sethlina Naa Dodua Aryee, George Davey Smith, Amy Davies, Yvonne E. Wren, Gemma C. Sharp, Kerry Humphries, Elisabeth Mangold, Lucy J. Goudswaard, Karen M. Ho, Tom Dudding, Sarah Jane Lewis

This study conducts GWAS on orofacial cleft subtypes, identifying 27 genome-wide significant regions, including novel loci, and highlights genetic heterogeneity and homogeneity across subtypes.

Human Molecular Genetics · Jul 29, 2025Peer-reviewedGenetic & Genomic Medicine

Association between genes regulating neural pathways for quantitative traits of speech and language disorders

Penelope H. Benchek, Robert P. Igo, Heather A. Voss-Hoynes, Yvonne E. Wren, Gabrielle J. Miller, Barbara J. Truitt, Wen Zhang, Michael D. Osterman, Lisa A. Freebairn, Jessica Tag, H. Gerry Taylor, E. Ricky Chan, Panos Roussos, Barbara Ann Lewis, Catherine M. Stein, Sudha K. Iyengar

This study identifies 18 significant genetic loci associated with speech sound disorders through GWAS and finds polygenic risk scores linked to clinical severity.

npj Genomic Medicine · Jul 27, 2021Peer-reviewedGenetic & Genomic Medicine

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

Christina Dardani, Laurence J Howe, Nandita Mukhopadhyay, Evie Stergiakouli, Yvonne E. Wren, Kerry Humphries, Amy Davies, Karen M. Ho, Seth Michael Weinberg, Mary L. Marazita, Elisabeth Mangold, Kerstin U. Ludwig, Caroline Laura Relton, George Davey Smith, Sarah Jane Lewis, , Gemma C. Sharp

This study investigates whether genetic liability to non-syndromic cleft lip/palate influences educational attainment and intelligence, finding little evidence of shared genetic causation.

International Journal of Epidemiology · Mar 6, 2020Peer-reviewedGenetics