Author

Sumi Lim

University College LondonORCID 0000-0002-1614-9753Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Jason RiheliD· 4 shared Güliz Gürel ÖzcaniD· 2 shared Aimee GoeliD· 1 shared David A. ProberiD· 1 shared David WhitmoreiD· 1 shared Eirinn MackayiD· 1 shared Elena DreostiiD· 1 shared Ellen J. HoffmaniD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

Jason RihelORCID

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4 papers

Recent·Most cited

Genetic and chemical disruption of Amyloid Precursor Protein processing impairs zebrafish sleep maintenance

Güliz Gürel Özcan, Sumi Lim, Thomas Canning, Lavitasha Tirathdas, Joshua Donnelly, Tanushree Kundu, Jason Rihel

This study shows that APP processing into Aβ40 and Aβ42 is conserved in zebrafish and that disrupting this processing affects sleep maintenance.

iScience · Jan 11, 2024Peer-reviewedNeuroscience

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

François Kroll, Gareth T. Powell, Marcus Ghosh, Gaia Gestri, Paride Antinucci, Timothy J. Hearn, Hande Tunbak, Sumi Lim, Harvey W Dennis, Joseph M. Fernandez, David Whitmore, Elena Dreosti, Stephen W. Wilson, Ellen J. Hoffman, Jason Rihel

This paper introduces a CRISPR-Cas9 method for rapid generation of F0 biallelic knockouts in zebrafish, enabling quick screening of complex phenotypes.

eLife · Jan 8, 2021Peer-reviewedGenetics

The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

Ida L. Barlow, Eirinn Mackay, Emily Wheater, Aimee Goel, Sumi Lim, Steve Zimmerman, Ian G. Woods, David A. Prober, Jason Rihel

The paper identifies a novel zebrafish sleep mutant, dreammist, and shows that disruption of a sodium pump regulator affects sleep duration through altered sodium homeostasis.

bioRxiv · Nov 18, 2020 · PreprintNeuroscience

Sleep is bi-directionally modified by amyloid beta oligomers

Güliz Gürel Özcan, Sumi Lim, Patricia L.A. Leighton, W. Ted Allison, Jason Rihel

This study shows that amyloid beta oligomers can either enhance or suppress sleep in zebrafish depending on their length, with distinct molecular mechanisms involved.

eLife · Jul 13, 2020Peer-reviewedNeuroscience