Jason Rihel

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.

JACUZI-SD is a method to induce sleep deprivation in larval zebrafish with minimal stress, reducing total sleep time by 41-64% and eliciting rebound sleep.

This study shows that meningeal scavenger cells clear brain waste more efficiently during wakefulness, regulated by both circadian rhythms and brain state.

This study shows that srrm3 regulates arousal states in zebrafish via cAMP signaling, with mutations causing hyperarousal and transcriptional changes.

This study demonstrates that CRISPR-CasRx reduces C9orf72 repeat RNAs and DPRs in vitro and in vivo, suggesting its therapeutic potential for ALS/FTD.

This study shows that sleep disruption improves performance in visual and olfactory decision-making tasks in larval zebrafish by increasing reaction times and correct decisions.

This study shows that APP processing into Aβ40 and Aβ42 is conserved in zebrafish and that disrupting this processing affects sleep maintenance.

The paper shows that sleep-dependent synapse loss in zebrafish neurons is regulated by sleep pressure, with synapse gains during wake and losses during sleep, particularly after prolonged wakefulness.

The paper investigates the role of noradrenergic tone in rebound sleep following neuronal activation in zebrafish, finding that reducing noradrenergic tone enhances rebound sleep.

The paper identifies two micropeptides encoded by lincRNAs that regulate chromatin accessibility in vertebrate-specific neural cells and show their role in brain development.

The paper identifies manganese deficiency and neurotoxicity in zebrafish slc39a14 mutants through transcriptome analysis, revealing key molecular pathways involved in manganese homeostasis disruption.

This paper introduces a CRISPR-Cas9 method for rapid generation of F0 biallelic knockouts in zebrafish, enabling quick screening of complex phenotypes.

The paper identifies a novel zebrafish sleep mutant, dreammist, and shows that disruption of a sodium pump regulator affects sleep duration through altered sodium homeostasis.

This study examines the phenotypic effects of SNX14 loss-of-function mutations in mice and zebrafish, revealing species-specific consequences despite conserved biochemical roles.

This study shows that amyloid beta oligomers can either enhance or suppress sleep in zebrafish depending on their length, with distinct molecular mechanisms involved.

This study develops computational tools to analyze larval zebrafish behavior across multiple timescales, revealing structured patterns and identifying novel phenotypes.

This study identifies Galanin as essential for rebound sleep following increased neuronal activity in zebrafish.