Biophysical basis of cellular multi-specificity encoded in a model molecular switch
Tina Perica, Christopher J.P. Mathy, Jiewei Xu…·Tanja Kortemme
The paper investigates how the GTPase Ran/Gsp1 achieves functional multi-specificity through biophysical and genetic perturbations, revealing that its effects are linked to kinetic parameters of the switch cycle rather than direct interaction sites.