Brian T. Luke

Elucidating the Mechanism by Which HIV-1 Nucleocapsid Mutations Confer Resistance to Integrase Strand Transfer Inhibitors

The paper shows HIV-1 NC mutations accelerate viral DNA integration and reduce INSTI sensitivity, acting with IN mutations to confer resistance.

In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals

This study detects HIV-1 antisense transcripts in vivo, showing higher expression in ART-treated individuals compared to untreated ones, suggesting a regulatory role in viral expression.

Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy

The paper compares HIV-1 proviral defects in children and adults on ART, finding more deletions and defects in children, especially in env and tat regions.

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

MoCoLo: a testing framework for motif co-localization

MoCoLo tests motif co-localization by analyzing reciprocal co-occurrence and accounting for confounders, confirming histone marker co-occurrence and oxidative DNA damage localization.

Tumor IsomiR Encyclopedia (TIE): a pan-cancer database of miRNA isoforms

The paper introduces TIE, a database of miRNA isoforms from tumor samples, demonstrating their functional relevance and providing tools for analysis.