Author

Hussein Al‐Mossawi

Immunocore (United Kingdom)ORCID 0000-0002-2312-3754Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hussein Al-Mossawi1 paper

Biology Disciplines

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Bioengineering· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:eQTL / molecular QTL mapping· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Benjamin Peter FairfaxiD· 2 shared Evelyn LauiD· 2 shared Isar NassiriiD· 2 shared Julian Charles KnightiD· 2 shared Sara DanielliiD· 2 shared Alexandra E. CuaycaliD· 1 shared Ana Laura ChiodettiiD· 1 shared Andrew M. LaddiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Benjamin Peter FairfaxORCID

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Author profile →

3 papers

Recent·Most cited

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

Matthew W. Becker, Matthew E. Brown, Katherine Wiseman, Ana Laura Chiodetti, Mollie K. Huber, Alexandra E. Cuaycal, Pumin Sintara, Sandra Mara Ferreira, Dylan Smurlick, Jessie M. Barra, Andrew M. Ladd, Denise Minerva Drotar, Mark A. Atkinson, Peter Weber, Hussein Al‐Mossawi, , Edward A. Phelps

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

bioRxiv · Oct 21, 2025 · PreprintBioengineering

Characterisation of the genetic determinants of context specific DNA methylation in primary monocytes

James J. Gilchrist, Hai Fang, Sara Danielli, Markéta Tomková, Isar Nassiri, Esther Ng, Orion Tong, Chelsea Alice Taylor, Hussein Al‐Mossawi, Evelyn Lau, Matt J. Neville, Benjamin Schuster‐Böckler, Julian Charles Knight, Benjamin Peter Fairfax

The paper characterizes genetic determinants of context-specific DNA methylation in primary monocytes exposed to inflammatory stimuli, identifying 209 CpGs under genetic control and linking them to disease.

bioRxiv · May 17, 2023 · PreprintGenetics

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele

Hussein Al-Mossawi, Nicole Yager, Chelsea Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C Knight, , Benjamin P Fairfax

The paper investigates how a genetic variant affects IL7R expression and soluble receptor secretion in monocytes under inflammatory conditions.

bioRxiv · Jul 15, 2018 · PreprintImmunology