Frederick R. Adler

Evolution of immune infiltration and immune triad formation across early melanoma progression

The paper investigates immune infiltration and triad formation in early melanoma progression using spatial transcriptomics, finding increased immune engagement in Stage I lesions compared to Stage 0.

Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis

The paper tracks clonal dynamics of spermatogonial stem cells in zebrafish over time and finds non-neutral drift patterns inconsistent with random chance.

Host genotype and sex shape influenza evolution and defective viral genomes

The paper shows host genotype and sex influence influenza virus evolution and defective genome formation through experimental adaptation and structural analysis.

What p53 sees: ATM and ATR activation through crosstalk between DNA damage response pathways

The paper constructs a mathematical model of ATM and ATR crosstalk in response to DNA damage, showing how crosstalk mechanisms influence pro-apoptotic signaling.

Ecological interactions in breast cancer: Cell facilitation promotes growth and survival under drug pressure

The paper shows that drug-sensitive breast cancer cells benefit from co-culture with resistant cells, which produce estradiol, leading to increased survival and resistance under treatment.

Reconstructing tumor trajectories during therapy through integration of multiple measurement modalities.

The paper reconstructs tumor size trajectories during therapy by integrating multiple measurement modalities to identify distinct patterns of tumor response and resistance.

Rolling Signal-based Ripley's K: A new algorithm to identify spatial patterns in histological specimens

This paper introduces a new statistical tool to identify spatial patterns in histological images, applied to murine bone marrow to reveal micro-niche structures in the hematopoietic stem cell microenvironment.

Dynamics of the p53 response to ionizing and ultraviolet radiation

This paper proposes a mathematical model explaining how p53 exhibits distinct dynamic responses to ionizing and ultraviolet radiation, with implications for cell fate decisions.