Author

Joshua J. Zimmerberg

National Institutes of HealthORCID 0000-0002-1707-3789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:electrophysiology· 2 Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Paul S. BlankiD· 3 shared Alexander J. SodtiD· 2 shared Frances MaleiD· 2 shared Gary E. WardiD· 2 shared Irene Jiménez-MunguíaiD· 2 shared Yuto KegawaiD· 2 shared Anne MosconaiD· 1 shared Avijit Sardar· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

Paul S. BlankORCID

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4 papers

Recent·Most cited

Fusion Peptide Insertion Configuration Determines the Mechanism of Membrane Curvature Induction in Human Parainfluenza Virus Type 3

Melanie A. Brunet, Laura J. S. Lopes, Nina Mansfield, Avijit Sardar, Tara C. Marcink, Paul S. Blank, Myriam L. Cotten, Anne Moscona, Alexander J. Sodt, Joshua J. Zimmerberg

This study identifies how different insertion configurations of the fusion peptide in HPIV3 influence membrane curvature during viral fusion.

bioRxiv · Oct 9, 2026 · PreprintBiophysics

The Influenza Hemagglutinin Cytoplasmic Tail Domain Interacts with Phosphatidylinositol 4,5-bisphosphate

David Winski, Matthew T. Parent, Jaqulin N. Wallace, Chamithri Weerakoon, Suman Shrestha, Prakash Raut, Hang N. Waters, Joshua J. Zimmerberg, Alexander J. Sodt

This paper investigates the interaction between influenza HA's cytoplasmic tail domain and PIP2 using MD and FPALM, finding electrostatic and hydrophobic contributions to HA-PIP2 binding.

bioRxiv · Aug 26, 2026 · PreprintBiophysics

Perforation of the host cell plasma membrane during Toxoplasma gondii invasion requires rhoptry exocytosis

Frances Male, Yuto Kegawa, Paul S. Blank, Irene Jiménez-Munguía, Saima May Sidik, Dylan Valleau, Sebastian Lourido, Maryse Lebrun, Joshua J. Zimmerberg, Gary E. Ward

This study confirms that Toxoplasma gondii induces a transient increase in host cell plasma membrane conductance during invasion, suggesting a perforation mechanism for rhoptry protein delivery.

EMBO Reports · Sep 19, 2025Peer-reviewedMicrobiology

The invasion pore induced by Toxoplasma gondii

Yuto Kegawa, Frances Male, Irene Jiménez-Munguía, Paul S. Blank, Elena Mekhedov, Gary E. Ward, Joshua J. Zimmerberg

The paper identifies a transient membrane conductance increase in host cells induced by Toxoplasma gondii, which precedes invasion and is termed the invasion pore.

EMBO Reports · Sep 19, 2025Peer-reviewedBiophysics