Gary E. Ward

This paper identifies UCB-9721 as a potent inhibitor of T. gondii MyoA, showing greater potency than KNX-002 and inhibiting related apicomplexan parasites.

The paper uses single-cell RNA profiling to show in vivo-derived Toxoplasma bradyzoites undergo two cell cycles, with AP2XI-6 playing a key role in one cycle essential for cyst maturation.

The paper identifies host N-glycosylation and cholesterol biosynthesis as required for Toxoplasma rhoptry discharge, mediated by the MIC1/4/6 complex clustering host factors.

This study confirms that Toxoplasma gondii induces a transient increase in host cell plasma membrane conductance during invasion, suggesting a perforation mechanism for rhoptry protein delivery.

The paper identifies a transient membrane conductance increase in host cells induced by Toxoplasma gondii, which precedes invasion and is termed the invasion pore.

This study compares motility and motility-dependent processes in Toxoplasma gondii tachyzoites and bradyzoites, revealing similarities and differences in their movement and invasion capabilities.