Frances Male

The paper identifies host N-glycosylation and cholesterol biosynthesis as required for Toxoplasma rhoptry discharge, mediated by the MIC1/4/6 complex clustering host factors.

This study confirms that Toxoplasma gondii induces a transient increase in host cell plasma membrane conductance during invasion, suggesting a perforation mechanism for rhoptry protein delivery.

The paper identifies a transient membrane conductance increase in host cells induced by Toxoplasma gondii, which precedes invasion and is termed the invasion pore.