Author

Manuel Lima Ferreira

University of WashingtonORCID 0000-0002-1720-7441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:electronic health records· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Andrew Lin KoiD· 3 shared Charles CobbsiD· 3 shared Christopher Dirk KeeneiD· 3 shared Daniel L. SilbergeldiD· 3 shared Ed S. LeiniD· 3 shared Jeff GoldyiD· 3 shared Jeffrey G. OjemanniD· 3 shared Jeremy A. MilleriD· 3 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Andrew Lin KoORCID

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Author profile →

4 papers

Recent·Most cited

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

H. Nayanga Thirimanne, Damian A. Almiron Bonnin, Nicholas Nuechterlein, Sonali Arora, Matt Jensen, Carolina Angelica Parada, Chengxiang Qiu, Frank Szulzewsky, Collin William English, William Chen, Philipp Sievers, Farshad Nassiri, Justin Z. Wang, Tiemo Jürgen Klisch, Kenneth D. Aldape, , Eric C. Holland

This study combines bulk RNA-Seq datasets to create a transcriptomic landscape of meningiomas, identifies subtypes with distinct biology and prognosis, and provides an interactive tool for outcome prediction.

Cell Genomics · May 23, 2024Peer-reviewedCancer Biology

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Thomas Chartrand, Rachel A. Dalley, Jennie Close, Natalia A. Goriounova, Brian Lee, Rusty Mann, Jeremy A. Miller, Gábor Molnár, Alice Mukora, Lauren Alfiler, Katherine S. Baker, Trygve E. Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, , Ed S. Lein

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Science · Oct 12, 2023Peer-reviewedNeuroscience

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

Brian Lee, Rachel A. Dalley, Jeremy A. Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine S. Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Éva Csajbók, Nicholas P. Donadio, , Ed S. Lein

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Science · Oct 12, 2023Peer-reviewedNeuroscience

Inter-individual variation in human cortical cell type abundance and expression

Nelson Johansen, Saroja Somasundaram, Kyle J. Travaglini, Anna Marie Yanny, Maya Shumyatcher, Tamara Casper, Charles Cobbs, Nick Dee, Richard G. Ellenbogen, Manuel Lima Ferreira, Jeff Goldy, Junitta Guzman, Ryder P. Gwinn, Daniel Hirschstein, Nikolas L. Jorstad, , Jeremy A. Miller

The paper assesses inter-individual variation in human cortical cell types across 75 individuals, finding significant variation in abundance and gene expression, particularly in deep layer glutamatergic neurons.

bioRxiv · Oct 7, 2022 · PreprintNeuroscience