Richard G. Ellenbogen

Analysis of gliomas DNA methylation: Assessment of pre-analytical variables.

This study assesses how pre-analytical variables affect DNA methylation analysis of the MGMT promoter in gliomas, finding that most variations do not significantly impact results but intratumor heterogeneity is prevalent.

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Inter-individual variation in human cortical cell type abundance and expression

The paper assesses inter-individual variation in human cortical cell types across 75 individuals, finding significant variation in abundance and gene expression, particularly in deep layer glutamatergic neurons.

Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex

The paper presents a synaptic physiology dataset and analysis platform to study cortical microcircuit structure and synaptic properties in mouse and human neocortex, revealing layer-dependent connectivity and subclass-specific dynamics.

Signature morpho-electric, transcriptomic, and dendritic properties of extratelencephalic-projecting human layer 5 neocortical pyramidal neurons

The paper identifies conserved and divergent morpho-electric and transcriptomic properties of human and rodent layer 5 extratelencephalic-projecting neurons using patch-seq in human brain slices.

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

This study uses ex vivo diffusion MRI and histopathology to correlate tract disruptions with axonal injury in a TBI patient.

Conserved cell types with divergent features between human and mouse cortex

The paper compares cell types in human and mouse cortex using single nucleus RNA-sequencing, finding conserved architecture with species-specific differences.

A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

This paper describes an ex vivo platform for studying adult human neocortical cell types and circuits using acute and cultured brain slices, enabling molecular-genetic manipulation and neuronal activity monitoring.