Toru Asahi

This study identifies de novo genes in crickets that arise from repetitive sequences, showing that such sequences are important in early gene evolution but not after gene establishment.

The paper investigates molecular mechanisms of maternal-induced embryonic diapause in crickets using genome assembly and time-series transcriptomic analyses, revealing epigenetic and metabolic changes.

The paper identifies osteopontin (OPN) upregulation as a conserved molecular signature of the pre-rupture state in thoracic aortic aneurysms across mice and humans.

This paper presents a high-quality chromosome-scale genome assembly for Gryllus bimaculatus using long-read sequencing and Hi-C data, significantly improving contiguity and gene annotation completeness.

This study identifies Praja1 as a DNA damage protector through direct DNA binding, showing its role in DNA repair and resistance to damage in cells and E. coli.

This study identifies Praja1 as an E3 ligase that ubiquitinates and degrades Tau, a key protein in tauopathies, and shows evolutionary conservation of this interaction.

This study shows that CB1R antagonists induce apoptosis in SH-SY5Y cells under serum-free conditions through mitochondrial dysfunction and ER stress.

This study shows that CB2 receptor deficiency reduces high-fat diet-induced peripheral neuroinflammation, suggesting CB2 can have pro-inflammatory effects under certain conditions.

This study compares vascularization strategies in human cerebral organoids using single-cell RNA sequencing to identify transcriptomic effects and cell interactions.

The paper uses immunohistochemistry to study Ser65-pUb distribution in mouse hippocampus, finding reduced levels in PINK1-deficient mice and partial colocalization with neuronal markers.