Douglas Michael Densmore

GROQ-seq Datasets Across Transcription Factors (LacI, RamR, VanR), T7 RNA Polymerase and TEV Protease

The paper introduces GROQ-seq, a high-throughput platform for linking protein function to sequencing data, and presents pilot datasets for transcription factors, polymerases, and proteases.

GROQ-seq Enables Cross-site Reproducibility for High-Throughput Measurement of Protein Function

This study demonstrates that GROQ-seq provides reproducible, scalable measurements of protein function across different facilities.

ICOR: Improving codon optimization with recurrent neural networks

ICOR uses recurrent neural networks to optimize codon usage for Escherichia coli, improving protein expression by considering sequential context beyond simple codon frequency.

Algorithms for the selection of fluorescent reporters

The paper presents algorithms and an open-source tool to optimize fluorophore panels for maximal signal and minimal bleed-through in fluorescent measurements.