Steven S. Rosenfeld

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

This study investigates how phosphorylation at Y211 regulates KIF11's mechanical properties during mitosis, showing it modulates motor velocity, force generation, and spindle dynamics.

This study identifies ATAT1 as a therapeutic target in glioblastoma by showing its role in promoting tumor invasion, proliferation, and resistance, with potential for combination therapies.

This study investigates how mTOR inhibition reverses glioma-induced changes in excitatory neurons, showing effects on mRNA, dendritic spines, and neuronal activity.

This study identifies STAT3 as a key driver of resistance to spindle inhibitors in glioblastoma, showing that therapy-induced senescence contributes to drug resistance by promoting quiescence and secreting factors that induce quiescence in proliferating cells.

This study shows that YAP inhibition with verteporfin increases radiosensitivity in chordoma by blocking DNA repair and causing G2M arrest.