Yuma Osako

Eye-specific drive and binocular suppression in mouse visual cortex during critical period development

This study investigates how ipsilateral and binocular visual responses develop in mouse visual cortex during the critical period, finding reciprocal interactions between ipsi inputs and binocular responses.

Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks

This study shows that mice and artificial neural networks reuse modular neuronal subspaces to perform complex cognitive tasks.

Parallel processing of orthogonal manifolds enables zero-shot composition in recurrent networks

This paper shows that feedback geometry in recurrent networks determines whether learned computations can be recombined through zero-shot parallel composition.

Internal state dynamically gates task-specific attractor dynamics in prefrontal cortex

The paper shows that motivational states modulate attractor dynamics in the medial prefrontal cortex during working memory tasks, revealing how internal states control neural dynamics and cognitive function.

Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cerebral organoids

This study examines how different MeCP2 mutations affect neuronal activity and network function in Rett syndrome organoids, finding mutation-specific impairments in connectivity and gene expression.

Learning sculpts orthogonal task manifolds for continual skill learning in recurrent networks

This paper shows that recurrent neural networks can learn new tasks without forgetting old ones by preserving task-specific latent dynamics through orthogonal task manifolds.

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

This study uses CRISPR/Cas9 to knockout Gat3 in mouse visual cortex astrocytes, revealing its role in shaping neuronal activity and sensory information encoding.

Behavioral expression of decision confidence engages disentangled confidence coding in the orbitofrontal cortex

The paper shows that task engagement in the orbitofrontal cortex aligns population activity along a confidence axis, enabling confidence-based behavior in rats.

Cortical astrocytes extend phasic norepinephrine signals and critically mediate learned behavior

The paper shows that cortical astrocytes mediate learned behavior by extending norepinephrine signals through calcium dynamics and ATP release, influencing neuronal encoding of task variables.

Prefrontal Cortex subregions provide distinct visual and behavioral feedback modulation to the Primary Visual Cortex

This study shows that distinct PFC subregions modulate VISp activity differently during behavior, with ACA enhancing visual encoding and ORB shaping movement and arousal-related responses.

An intra-oral flavor discrimination task in freely moving mice

This paper introduces a novel behavioral task for flavor discrimination in mice, showing that intraoral flavor, not olfactory input, is critical for task performance.

Emotional association enhances perceptual memory through amygdalo-cortical inputs during NREM sleep

The paper shows emotional association enhances perceptual memory through BLA-frontal projections during NREM sleep by increasing coordinated reactivation and disrupting memory retention when BLA inputs are silenced.

Reward priming differentially modulates enhancement and inhibition in auditory decision-making

This study examines how explicit knowledge of reward irrelevancy affects reward priming in auditory decision-making, showing that explicit instruction leads to both enhancement and inhibition, while implicit instruction only results in inhibition.

Dynamic coordination of the perirhinal cortical neurons supports coherent representations between task epochs

The paper examines how perirhinal cortical neurons encode different choice directions across task epochs and identifies neural subspaces that reflect coordinated patterns.

Visually-evoked choice behavior driven by distinct population computations with non-sensory neurons in visual cortical areas

The paper investigates how non-sensory neurons in V1 and PPC contribute to population-level computations that drive visually-evoked choice behavior during a detection task.

Temporal dynamics of endogenous attentional modulation without cue awareness

This study investigates how endogenous attentional modulation changes over time when participants are unaware of the cue direction, finding that its effect is time-dependent and diminishes with longer delays.