Author

Nikita Kadakia

University of California San DiegoORCID 0000-0002-1884-1671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Joshua ChiouiD· 3 shared Kyle J. GaultoniD· 3 shared Mei-Lin Okino· 3 shared Anthony AylwardiD· 2 shared Jee Yun HaniD· 2 shared Maike SanderiD· 2 shared Allen WangiD· 1 shared Bing ReniD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSystems Biology

Joshua ChiouORCID

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Author profile →

3 papers

Recent·Most cited

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

Gaowei Wang, Joshua Chiou, Chun Zeng, Michael Miller, Ileana Matta, Jee Yun Han, Nikita Kadakia, Mei-Lin Okino, Elisha Beebe, Medhavi Mallick, Joan Camuñas-Soler, Theodore dos Santos, Xiao-Qing Dai, Cara E. Ellis, Yan Hang, , Maike Sander

The paper integrates single-cell multiomic data with genetics to identify gene regulatory changes in beta cells associated with type 2 diabetes.

bioRxiv · Dec 31, 2022 · PreprintSystems Biology

Pancreatic islet chromatin accessibility and conformation defines distal enhancer networks of type 2 diabetes risk

William W. Young Greenwald, Joshua Chiou, Jian Yan, Yunjiang Qiu, Ning Dai, Allen Wang, Naoki Nariai, Anthony Aylward, Jee Yun Han, Nikita Kadakia, Laura Regué, Mei-Lin Okino, Frauke Drees, Dana Krämer, Nicholas K. Vinckier, , Kyle J. Gaulton

The paper identifies distal enhancer networks in pancreatic islets associated with type 2 diabetes risk by integrating chromatin accessibility, conformation, and genetic data.

Nature Communications · May 7, 2019Peer-reviewedGenomics

Shared genetic contribution to type 1 and type 2 diabetes risk

Anthony Aylward, Joshua Chiou, Mei-Lin Okino, Nikita Kadakia, Kyle J. Gaulton

This study identifies shared genetic risk factors between type 1 and type 2 diabetes, showing overlapping regulatory elements and causal variants affecting islet function and growth.

bioRxiv · May 7, 2018 · PreprintGenetics