Workload-induced changes to cell state contribute to β-cell failure in diabetes
Somesh Sai, Fenfen Liu, Austin R. Harrington, Han Zhu, Ibrahim Omar, Chun Zeng, Medhavi Mallick, Yinghui Sui, Maike Sander, Matthew Wortham
This study shows workload-induced β-cell overstimulation leads to failure in T2D, identifying a compensating transcriptional state and the role of Lsd1 in restraining state transitions.
bioRxiv · May 18, 2026 · PreprintPhysiology