Author

Fei Gu

Boston Children's HospitalORCID 0000-0002-7725-3909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

William T. PuiD· 2 shared Amanda Davenport· 1 shared Andrew P. BlairiD· 1 shared Bart DeplanckeiD· 1 shared Bayardo I. GarayiD· 1 shared Benoit G. BruneauiD· 1 shared Binghao Liu· 1 shared Brynn N. AkerbergiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersDevelopmental Biology

William T. PuORCID

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3 papers

Recent·Most cited

Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue

Pingzhu Zhou, Chase W. Kessinger, Fei Gu, Amanda Davenport, Justin S. King, Genyu Wang, Steven G. Negron, Bart Deplancke, William T. Pu, Zhiqiang Lin

This study identifies VGLL4 as a regulator of classical brown adipose tissue development by modulating the Hippo-YAP pathway and adipogenic gene expression.

Journal of Molecular and Cellular Cardiology Plus · Jun 1, 2025Peer-reviewedDevelopmental Biology

Multimodal foundation model predicts zero-shot functional perturbations and cell fate dynamics

Zikun Yang, Xueying Fan, Meng Lan, Xubo Tang, Zhijie Zheng, Binghao Liu, Yue You, Luyi Tian, George McDonald Church, Xiaodong Liu, Fei Gu

PertFormer, a multimodal foundation model, predicts zero-shot functional perturbations and cell fate dynamics, outperforming existing methods and identifying novel tumor treatment targets.

bioRxiv · Dec 19, 2024 · PreprintGenomics

Modeling human TBX5 haploinsufficiency predicts regulatory networks for congenital heart disease

Irfan S. Kathiriya, Kavitha S. Rao, Giovanni Lo Iacono, Walter Patrick Devine, Andrew P. Blair, Swetansu K. Hota, Michael H. Lai, Bayardo I. Garay, Reuben Thomas, Henry Z. Gong, Lauren K. Wasson, Piyush Goyal, Tatyana Sukonnik, Kevin M. Hu, Gunes A. Akgun, , Benoit G. Bruneau

The paper models TBX5 haploinsufficiency in iPSC-derived cardiomyocytes to identify gene regulatory network imbalances linked to congenital heart disease.

Developmental Cell · Dec 15, 2020Peer-reviewedDevelopmental Biology