This study identifies VGLL4 as a regulator of classical brown adipose tissue development by modulating the Hippo-YAP pathway and adipogenic gene expression.

Journal of Molecular and Cellular Cardiology Plus · Jun 1, 2025Peer-reviewedDevelopmental Biology

Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing

Yanjiang Zheng, Joshua Mayourian, Justin S. King, Yifei Li, Vassilios J. Bezzerides, William T. Pu, Nathan J. VanDusen

This study applies CASAAV-HDR to model cardiomyopathies and perform functional genomics in mouse cardiomyocytes, showing its utility for disease modeling and enhancer analysis.

bioRxiv · Dec 3, 2024 · PreprintGenetics

Effects of Aging on the Immune and Periosteal Response to Fracture in Mice

Justin S. King, Matthew Wan, Adam Kim, Shagun Prabhu, Sanja Novak, Ivo Kalajzić, Anne M. Delany, Archana Sanjay

This study examines how aging affects immune and periosteal responses to fracture in mice, finding reduced proliferative capacity of periosteal stem/progenitor cells and increased CD8+ T cell recruitment in aged mice.

Bone · Nov 6, 2024Peer-reviewedCell Biology

In vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation

Nathan J. VanDusen, Julianna Y. Lee, Weiliang Gu, Isha Sethi, Yanjiang Zheng, Justin S. King, Pingzhu Zhou, Shengbao Suo, Yuxuan Guo, Qing Ma, Guo‐Cheng Yuan, William T. Pu

bioRxiv · Oct 17, 2019 · PreprintGenetics