Author

Naoya Asai

Fujita Health UniversityORCID 0000-0002-1930-0447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Atsushi EnomotoiD· 2 shared Akihiko YoshimuraiD· 1 shared Daisuke MotookaiD· 1 shared Daisuke SugiyamaiD· 1 shared Eiko SakuraiiD· 1 shared Fuyang Cao· 1 shared Hiroshi ArimaiD· 1 shared Hiroshi KimuraiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Atsushi EnomotoORCID

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2 papers

Recent·Most cited

Leptin receptor deficiency suppresses gastric tumorigenesis by limiting stromal activation and tumor microenvironment development.

Kyoko Inagaki‐Ohara, Daisuke Motooka, Itaru Yamanaka, T. Nakayama, Shaniya Abudureyimu, Hiroyuki Tezuka, Eiko Sakurai, Kaori Ushida, Takuya Kato, Shizuko Nagao, Yasuhiko Minokoshi, Akihiko Yoshimura, Atsushi Enomoto, Naoya Asai

bioRxiv · Oct 13, 2026 · PreprintCancer Biology

Local, but not circulating, complement C3 governs immune checkpoint blockade efficacy

Yuki Miyai, Yukihiro Shiraki, Daisuke Sugiyama, Yoshitaka Sato, Katsuhiro Kato, Naoya Asai, Fuyang Cao, Nobuyoshi Nagao, Kana Tanabe, Masahiro Nakatochi, Tetsunari Hase, Tetsushi Yoshikawa, Tomoko Kobayashi, Shintaro Iwama, Nobutoshi Esaki, , Atsushi Enomoto

This study shows that locally produced C3 in cancer-associated fibroblasts, not circulating C3, determines immune checkpoint blockade efficacy by modulating myeloid cell infiltration.

bioRxiv · May 12, 2025 · PreprintCancer Biology