François Spitz

This study uses TATTOO-seq to identify spatial and cell type-specific regulatory programs during limb development and shows how perturbations affect cell fate and spatial organization.

The paper uses in vivo CRISPR editing to analyze Fgf8 regulatory elements in the AER and MHB, revealing distinct patterns of enhancer redundancy and function.

The paper investigates the development of extraocular muscles, identifying retinoic acid's role in their formation and tendon attachment sites.

This study shows that deleting Ncaph2 in mouse hepatocytes does not alter chromatin folding or gene expression, suggesting condensin II's role in interphase may be limited.

The paper uses whole-organism single-cell RNA-seq to analyze cell type diversity in Nematostella vectensis, identifying 35% of genes and 51% of TFs as cell type-specific.

This study shows that cohesin removal leads to loss of TADs and loops but preserves compartments, revealing two independent modes of chromosome organization.