Author

Oana Pelea

John Radcliffe HospitalORCID 0000-0002-1968-9827Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Tatjana Sauka‐SpengleriD· 2 shared Tudor A. FulgaiD· 2 shared Andrew RamosiD· 1 shared Anusha RajaniD· 1 shared Elena Zanchini di Castiglionchio· 1 shared Jesús A. Siller‐FarfániD· 1 shared Omer DushekiD· 1 shared Quentin R. V. FerryiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Tatjana Sauka‐SpenglerORCID

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2 papers

Recent·Most cited

Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos

Oana Pelea, Sarah Mayes, Quentin R. V. Ferry, Tudor A. Fulga, Tatjana Sauka‐Spengler

This paper introduces a method to modulate CRISPR activity in response to RNA detection using engineered guide RNAs, demonstrating functionality in mammalian cells and zebrafish embryos.

eLife · Jul 8, 2025Peer-reviewedSynthetic Biology

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function

Andrew Ramos, Sylvain Simon, Jesús A. Siller‐Farfán, Anusha Rajan, Santiago Revale, Elena Zanchini di Castiglionchio, Oana Pelea, Tudor A. Fulga, Stanley R. Riddell, Omer Dushek, Yale S. Michaels, Tatjana Sauka‐Spengler

This study shows that varying CAR expression levels in T cells affects their activation, function, and transcriptional identity, with optimal CAR levels preventing exhaustion.

bioRxiv · Feb 10, 2025 · PreprintSynthetic Biology