Author

Jesús A. Siller‐Farfán

University of OxfordORCID 0000-0001-6624-7637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Omer DushekiD· 2 shared Andrew RamosiD· 1 shared Anusha RajaniD· 1 shared Edward M. JenkinsiD· 1 shared Elena Zanchini di Castiglionchio· 1 shared Jake BurtoniD· 1 shared Jose Cabezas-CaballeroiD· 1 shared Michael I. BartoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersSynthetic Biology

Omer DushekORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintFeb 10, 2025

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function

Andrew Ramos, Sylvain Simon, Jesús A. Siller‐Farfán…·Tatjana Sauka‐Spengler

This study shows that varying CAR expression levels in T cells affects their activation, function, and transcriptional identity, with optimal CAR levels preventing exhaustion.

DOI 10.1101/2025.02.10.637482

humanscRNA-seq

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ImmunologybioRxivPreprintJan 6, 2025

Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes

Jake Burton, Jesús A. Siller‐Farfán, Violaine André…·Omer Dushek

The antigen sensitivity of CAR-T cells can be tuned to match the sensitivity of TCR-T cells by varying the relative extracellular size of CAR/antigen and CD2/CD58 complexes.

2 citations

humanproteomics

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