Hiroaki Sakaue

Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention

This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.

Comparative Evaluation of Glycoproteomics Software for Rare Glycopeptide Identification

This study evaluates five glycoproteomics software tools for identifying rare sialic acid-containing glycopeptides, finding that each tool has unique strengths and limitations in detection accuracy and reliability.

GRable version 1.0: A software tool for site-specific glycoform analysis with improved MS1-based glycopeptide detection with parallel clustering and confidence evaluation with MS2 information

Combinatorial approach with mass spectrometry and lectin microarray dissected glycoproteomic features of virion-derived spike protein of SARS-CoV-2

The paper identifies site-specific glycan compositions of SARS-CoV-2 spike protein using mass spectrometry and lectin microarray, revealing key glycan structures relevant to vaccine design.